Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of rifabutin
Drug 1
Drug 1 dose
600 mg daily
Drug 1 effect
Not studied
Drug 2
Drug 2 dose
300 mg or 450 mg twice weekly
Drug 2 effect
On 300 mg rifabutin twice weekly, rifabutin level 2 hours after dose: no significant change; rifabutin level 6 hours post dose: decreased 27%; on 450 mg twice weekly, rifabutin level 2 hours post dose: no significant change; rifabutin level 6 hours post dose: decreased 58%(all values compared to rifabutin alone)
Clinical Effects
Potential decreased rifabutin effects
Management
Increase rifabutin to 450-600 mg daily. May use rifabutin 300 mg three times weekly if not coadministered with a protease inhibitor
Import ID
375
