Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of rifabutin
Drug 1
Drug 1 dose
600 mg x 14 days
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
300 mg daily x 14 days
Drug 2 effect
Rifabutin AUC decreased 38%; Cmax decreased 32%; Cmin decreased 45%
Clinical Effects
Decreased rifabutin effects
Management
Increase rifabutin to 450-600 mg daily. May use rifabutin 300 mg three times weekly if not coadministered with a protease inhibitor
Import ID
373
