Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of pravastatin
Drug 1
Drug 1 dose
600 mg daily x 15 days
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
40 mg daily x 4 days
Drug 2 effect
Pravastatin AUC decreased 44%; Cmax decreased 32%; Cmin decreased 19%
Clinical Effects
Decreased pravastatin effects
Management
Monitor statin efficacy. May need to increase pravastatin dose
Import ID
371
