Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
600 mg daily over period of 60 weeks
Drug 2
Drug 2 dose
stable dose over period of 60 weeks
Drug 2 effect
Methadone AUC decreased 39%; Cmax decreased 33%; Cmin decreased 44%EDDP (methadone metabolite) AUC decreased 14.5%; Cmax no significant change; Cmin no significant change
Clinical Effects
Decreased methadone effects (eg, withdrawal)
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose. In one study patients required mean dose increase of 30% over period of 60 weeks.
Import ID
369
