Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
600 mg daily x 14 days
Drug 1 effect
Not studied
Drug 2
Drug 2 effect
Methadone AUC decreased 57%; Cmax decreased 48%
Clinical Effects
Decreased methadone effects (eg, withdrawal)
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose. In one study patients required mean dose increase of 30% over period of 60 weeks.
Import ID
368
