Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of methadone
Drug 1
Drug 1 dose
600 mg x 14-21 days
Drug 2
Drug 2 dose
35-100 mg daily
Drug 2 effect
Methadone AUC decreased 52%; Cmax decreased 45%
Clinical Effects
Decreased methadone effects (eg, withdrawal)
Management
If coadministering monitor for signs and symptoms of methadone withdrawal. Some patients may require an increased methadone dose. In one study patients required mean dose increase of 30% over period of 60 weeks.
Import ID
366
