Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of dolutegravir
Drug 1
Drug 1 dose
600 mg daily
Drug 2
Drug 2 dose
50 mg daily
Drug 2 effect
Dolutegravir AUC decreased 57%; Cmin decreased 75%
Clinical Effects
Potentially reduced dolutegravir effectiveness
Management
If no INSTI resistance, increase dolutegravir dosage to 50 mg BID. If known or clinically suspected INSTI resistance, use alternative combination
Import ID
362
