Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of doravirine
Drug 1
Drug 1 dose
100 mg x 1
Drug 1 effect
AUC decreased 88%; Cmax decreased 57%, Cmin decreased 97%
Drug 2
Drug 2 dose
600 mg daily
Drug 2 effect
Not studied
Clinical Effects
Potential decrease in antiretroviral efficacy.
Management
Contraindicated. Use alternative agents. If discontinuing the rifamycin, at least a 4 week cessation period is recommended prior to beginning doravirine.
Import ID
357
