Isentress / Isentress HD package insert
Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
400 mg BID on days 1-5 and days 13-26
Drug 1 effect
Raltegravir AUC increased 54%; Cmin increased 48%; Cmax increased 39%
Drug 2
Drug 2 dose
300 mg BID on days 6-12 and days 13-26
Drug 2 effect
Atazanavir AUC decreased 17%; Cmin decreased 29% (compared to atazanavir BID)
Clinical Effects
Potential for increased raltegravir effects
Import ID
289
