Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of raltegravir
Drug 1
Drug 1 dose
800 mg Q12H
Drug 1 effect
Raltegravir AUC increased 27%; Cmin decreased 53%; Cmax increased 62% (compared to 400 mg raltegravir Q12H when given alone)
Drug 2
Drug 2 dose
600 mg daily
Management
Dose raltegravir 800 mg orally twice daily. Do not coadminister raltegravir 1200 mg once daily with rifampin.
Alternative Agents
Rifabutin
Import ID
283
