Isentress / Isentress HD package insert
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of raltegravir
Drug 1
Drug 1 dose
800 mg BID
Drug 1 effect
Raltegravir AUC increased 27%; Cmax increased 62%; Cmin decreased 53% (all compared to raltegravir 400 mg BID)
Drug 2
Drug 2 dose
600 mg daily
Drug 2 effect
Not reported
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Dose raltegravir 800 mg orally twice daily. Do not coadminister raltegravir 1200 mg once daily with rifampin.
Alternative Agents
Rifabutin
Import ID
282
