Isentress / Isentress HD package insert
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of raltegravir
Drug 1
Drug 1 dose
400 mg x 1
Drug 1 effect
Raltegravir AUC decreased 40%; Cmax decreased 38%; Cmin decreased 61%
Drug 2
Drug 2 dose
600 mg daily
Drug 2 effect
Not reported
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Dose raltegravir 800 mg orally twice daily. Do not coadminister raltegravir 1200 mg once daily with rifampin.
Alternative Agents
Rifabutin
Import ID
281
