Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of bosentan
Drug 1
Drug 2
Clinical Effects
Potential for increased risk of bosentan adverse effects
Management
If patient has been on elvitegravir / cobicistat for more than 10 days, start with bosentan dose of 62.5 mg daily or every other day. If patient is currently on bosentan and requires use of elvitegravir / cobicistat, stop bosentan for at least 36 hours prior to initiating ART. Wait 10 days and then resume bosentan starting with 62.5 mg daily or every other day.
Import ID
154
