Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
150 mg elvitegravir / 150 mg cobicistat once daily
Drug 1 effect
Cmax decreased 21%; AUC decreased 6%; Cmin increased 32%
Drug 2 dose
400 / 100 / 100 mg plus 100 mg voxilaprevir
Drug 2 effect
Voxilaprevir Cmax increased 92%; AUC increased 171%; Cmin increased 350%. Velpatasvir AUC increased 16%; Cmin increased 46%. Sofosbuvir Cmax increased 27%; AUC increased 22%
Management
If coadministering with Stribild, monitor for TDF related adverse effects. Consider monitoring for hepatotoxicity when coadministering with either Stribild or Genvoya
Import ID
140
