Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction: risks likely to outweigh benefits
Drug 1
Drug 1 dose
150 mg elvitegravir / 150 mg cobicistat once daily
Drug 1 effect
Not reported
Drug 2 dose
0.18 / 0.215 / 0.250 mg NGM once daily, 0.025 mg EE once daily
Drug 2 effect
Ethinyl estradiol Cmax decrease 6%, AUC decrease 25%, Cmin decrease 44%; Norgestimate Cmax increased 108%, AUC increased 126%, Cmin increased 167%
Clinical Effects
Potential for increased norgestimate effects (e.g. insulin resistance, dyslipidemia, acne, venous thrombosis); Potential decreased ethinyl estradiol effects
Management
Additional or alternative contraception should be considered.
Import ID
137
