Interaction Color Code
Clinical Bottom Line
Administer standard doses
Drug 1
Drug 1 dose
150 mg elvitegravir / 150 mg cobicistat once daily
Drug 1 effect
Not reported
Drug 2
Drug 2 dose
16-24 mg once daily
Drug 2 effect
Buprenorphine Cmax increased 12%, AUC increased 35%, Cmin increased 66%. Norbuprenorphine metabolite Cmax increased 24%, AUC increased 42%, Cmin increased 57%
Clinical Effects
Potential for increased risk of sedation and decreased cognition
Management
If using, monitor closely for excess sedation and cognitive effects
Import ID
129
