Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of rosuvastatin
Drug 1
Drug 1 dose
150 mg elvitegravir / 150 mg cobicistat single dose
Drug 1 effect
No significant change
Drug 2
Drug 2 dose
10 mg single dose
Drug 2 effect
Cmax increased 89%, AUC increased 38%, Cmin increased 43%
Clinical Effects
Potential for increased risk of rosuvastatin adverse effects (e.g. myopathy)
Management
Initiate rosuvastatin at lowest dose and titrate carefully. Monitor for adverse effects.
Import ID
128
