Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of atorvastain
Drug 1
Drug 1 dose
150 mg elvitegravir / 150 mg cobicistat once daily
Drug 1 effect
AUC decreased 8%
Drug 2
Drug 2 dose
10 mg single dose
Drug 2 effect
Cmax increased 132%; AUC increased 160%.
Clinical Effects
Potential for increased atorvastatin adverse effects (e.g. myopathy)
Management
Initiate with lowest Potential dose of atorvastatin. Titrate carefully while monitoring for adverse effects. Do not exceed 20 mg of atorvastatin daily.
Import ID
127
