Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of dolutegravir
Drug 1
Drug 1 dose
50 mg once daily
Drug 1 effect
Cmax decreased 52%, AUC decreased 71%, Cmin decreased 88%
Drug 2
Drug 2 dose
200 mg once daily
Drug 2 effect
Not studied
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Contraindicated. Use in combination with ATV / r or DRV / r
Import ID
123
