Dolutegravir SOF/VEL 112

Interaction Color Code

Green: Administer standard doses

Clinical Bottom Line

Administer standard doses

Drug 1

Dolutegravir

Drug 1 dose

50 mg once daily

Drug 1 effect

Not studied

Drug 2

Sofosbuvir / Velpatasvir

Drug 2 dose

400 / 100 mg daily

Drug 2 effect

Sofosbuvir Cmax decreased 12%, AUC decreased 8%. No significant change in sofosbuvir metabolite GS-331007. Velpatasvir Cmax decreased 6%, AUC decreased 9%, Cmin decreased 12%.

Import ID

112