Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of dolutegravir
Drug 1
Drug 1 dose
50 mg single dose
Drug 1 effect
Cmax decreased 57%, AUC decreased 54%, Cmin decreased 56% when administered simultaneously with ferrous fumarate, fasting conditions. No significant change in dolutegravir Cmax or AUC if given simultaneously with ferrous fumarate, with food or if given 2 hours after ferrous fumarate.
Drug 2
Drug 2 dose
324 mg
Drug 2 effect
Not studied
Clinical Effects
Potential decrease in antiretroviral efficacy if given with iron.
Management
Administer dolutegravir 2 hours before or 6 hours after taking medications containing polyvalent cations. Alternatively, administer dolutegravir simulatenously with iron supplements and with food.
Import ID
96
