Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of dolutegravir
Drug 1
Drug 1 dose
50 mg once daily
Drug 1 effect
Cmax decreased 39%, AUC decreased 57%, Cmin decreased 75%
Drug 2
Drug 2 dose
600 mg once daily
Drug 2 effect
Not studied
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Adjust dose of dolutegravir to 50 mg twice daily for treatment-naive and treatment experienced, INSTI naive adult patients, in pediatrics, increased the weight-based dose to twice daily, Use alternate combinations in INSTI experienced or INSTI resistance patients
Import ID
89
