Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of metformin
Drug 1
Drug 1 dose
50 mg once daily or 50 mg BID
Drug 1 effect
Not studied
Drug 2
Drug 2 dose
500 mg BID
Drug 2 effect
Cmax increased 66%, AUC increased 79%, Cmin increased 9% when given with dolutegravir once daily. If given with dolutegravir 50 mg BID, then metformin Cmax increased 111%, AUC increased 145%, and Cmin increased 14%
Clinical Effects
Potential increased adverse effects from metformin (e.g. GI side effects).
Management
Limit metformin dose to 1,000 mg per day. When starting / stopping DTG in patient on metformin, dose adjustment of metformin may be necessary to maintain optimal glycemic control and / or minimize GI symptoms.
Import ID
86
