Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of bictegravir
Drug 1
Drug 1 dose
75 mg once daily
Drug 1 effect
Cmax decreased 20%, AUC decreased 38%, Cmin decreased 56%
Drug 2
Drug 2 dose
300 mg once daily (fasted)
Drug 2 effect
Not reported
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Use alternative agents
Import ID
82
