Interaction Color Code
Clinical Bottom Line
Do not coadminister: Reduced levels of bictegravir
Drug 1
Drug 1 dose
75 mg once daily
Drug 1 effect
Cmax decreased 28%, AUC decreased 75%
Drug 2
Drug 2 dose
600 mg once daily (fed state)
Drug 2 effect
Not reported
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Contraindicated. Use alternative agents.
Import ID
81
