Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid reduced levels of bictegravir
Drug 1
Drug 1 dose
50 mg single dose
Drug 1 effect
If administered simultaneously in the fasted state Cmax decreased 71%, AUC decreased 63%. If administered simultaneously in the fed state Cmax decreased 25%, AUC decreased 16%
Drug 2
Drug 2 dose
324 mg single dose
Drug 2 effect
Not reported
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Bictegravir should be administered simultaenously with iron supplements, with food. Monitor for virologic efficacy.
Import ID
65
