Selzentry package insert
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid decreased levels of maraviroc
Drug 1
Drug 1 dose
100 mg BID
Drug 1 effect
Maraviroc AUC decreased 63%; Cmax decreased 66%; Cmin decreased 78%
Drug 2
Drug 2 dose
600 mg daily
Drug 2 effect
Not reported
Clinical Effects
Potential decrease in antiretroviral efficacy
Management
Increase maraviroc dose to 600 mg BID. If also including a strong CYP3A4 inhibitor in the regimen, consider using an alternative agent due to difficulty predicting maraviroc concentrations.
Import ID
33
