Rukobia package insert
Interaction Color Code
Clinical Bottom Line
Minimal data to guide interaction, weigh risks and benefits of using this combination
Drug 1
Drug 1 dose
600 mg BID
Drug 1 effect
Not reported
Drug 2 dose
0.030 / 1.5mg once daily
Drug 2 effect
EE: Cmax increased 39%, AUC increased 40%; NE: Cmax increased 8%, AUC increased 8%
Clinical Effects
Increased ethinyl estradiol exposure and increased risk of thromboembolic events
Management
If co-adminstering, ethinyl estradiol daily dose should not exceed 30 mcg. Further caution advised if patient is at increased risk for thromboembolic events.
Import ID
25
