Rukobia package insert
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of rifabutin
Drug 1
Drug 1 dose
600 mg BID
Drug 1 effect
Temsavir Cmax decreased 27%, AUC decreased 30%, Cmin decreased 41%
Drug 2
Drug 2 dose
300 mg once daily
Drug 2 effect
Not reported
Management
Use standard dose rifabutin if coadministering with fostemsavir. If using fostemsavir in combination with a ritonavir boosted protease inhibitor, lower rifabutin dose to 150 mg daily.
Import ID
2
