Rukobia package insert
Interaction Color Code
Clinical Bottom Line
Adjust dosing to avoid increased levels of rifabutin
Drug 1
Drug 1 dose
600 mg BID
Drug 1 effect
Temsavir Cmax increased 50%, AUC increased 66%, Cmin increased 158%
Drug 2
Drug 2 dose
RFB 150 mg once daily, RTV 100 mg once daily
Drug 2 effect
Not reported
Management
Use standard dose rifabutin if coadministering with fostemsavir. If using fostemsavir in combination with a ritonavir boosted protease inhibitor, lower rifabutin dose to 150 mg daily.
Import ID
1
