Lamivudine

ARV U.S. Brand Name

Epivir

ARV Abbreviation(s)

3TC

U.S. FDA Label

Lamivudine Labeling (Package Inserts)

ARV Class

Nucleoside reverse transcriptase inhibitors

First U.S. Approval

November 17, 1995

U.S. Manufacturer

ViiV Healthcare

Formulations

Strength	Formulation	Image	Description	Boosted
150 mg	Tablet	X	oval white tablet with GX\|CJ7 imprint	No
300 mg	Tablet	X	oval light blue tablet with GX\|EJ7 imprint	No
10-mg/mL	Oral Solution	X	white bottle. label with epivir/lamivudine oral solution alcohol free	No

Generic Available?

Yes

Other Reference Links

Clinical Info HIV Drug Database

National HIV Curriculum

FDCs

Abacavir / Dolutegravir / Lamivudine

Dolutegravir / Lamivudine

Doravirine / Lamivudine / Tenofovir DF

Abacavir / Lamivudine

Abacavir / Lamivudine / Zidovudine

Lamivudine / Tenofovir DF

Lamivudine / Tenofovir DF

Efavirenz / Lamivudine / Tenofovir DF

Assistance Programs

Displaying 1 - 14 of 14

	Interaction Color Code	Clinical Bottom Line	Clinical Effects	Drug 1 effect	Drug 2 dose	Drug 2 effect	Management
Tenofovir disoproxil fumarate 3TC 734	Green: Administer standard doses	Administer standard doses		No significant change	150 mg BID	Cmax decrease 24%
Lamivudine Sorbitol 701	Orange: Minimal data to guide interaction	Minimal data to guide interaction: risks likely to outweigh benefits	Potentially decreased lamivudine efficacy	AUC decreased 20-44%	3.2 - 13.4 grams daily	Not studied	Consider using alternative agents. Interaction studied with liquid formulation. If unable to avoid co-administration, monitor for virologic efficacy.
Lamivudine Ribavirin 700	Green: Administer standard doses	Administer standard doses		No significant change	800 mg daily
Lamivudine ATV 699	Green: Administer standard doses	Administer standard doses		No significant change	400 mg daily x 6 days	Not studied
Lamivudine Methadone 698	Green: Administer standard doses	Administer standard doses		Not studied		No significant change
Lamivudine Entecavir 697	Green: Administer standard doses	Administer standard doses		No significant change		No significant change
Lamivudine Buprenorphine / naloxone 696	Green: Administer standard doses	Administer standard doses			14 mg daily	No significant change
Lamivudine Interferon alfa 695	Green: Administer standard doses	Administer standard doses		No significant change	10 MU three times weekly	No significant change
Lamivudine Adefovir 694	Green: Administer standard doses	Administer standard doses		Not studied	10 mg daily	No significant change
Lamivudine G/P 693	Green: Administer standard doses	Administer standard doses		No significant change	300 mg / 120 mg daily	GLE AUC decrease 25%, PIB AUC decrease 28%
Lamivudine TMP/SMX 692	Green: Administer standard doses	Administer standard doses	Potentially increased lamivudine adverse effects	Lamivudine AUC increased 44%	160 mg / 800 mg daily x 5 days	Not studied
Abacavir 3TC 669	Green: Administer standard doses	Administer standard doses		No significant change	150 mg x 1 dose	Lamivudine Cmax decreased 35%; AUC decreased 15%
Efavirenz 3TC 424	Green: Administer standard doses	Administer standard doses		Not studied	150 mg Q12H x 14 days	No significant change
Lamivudine

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